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Search Results for " L DOPA "

18

阻害剤

9

天然化合物

2

リコンビナントタンパク質

カタログ番号 製品名 別名 ターゲット
T31570 DPBX-L-Dopa DPBX L-Dopa
DPBX-L-Dopa is a boron-containing dopa-derivative, acting as a bladder relaxant through non-catecholamine receptors.
T36122 3-O-methyl-L-DOPA (hydrate)
3-O-methyl-L-DOPA is a metabolite of L-DOPA , produced by the activity of catechol O-methyltransferase. 3-O-methyl-L-DOPA may have effects of its own or it may compete with the actions of L-DOPA.
T24047 Etilevodopa hydrochloride Levodopa ethyl ester,Etilevodopa HClL-DOPA ethyl ester Others , Dopamine Receptor , Drug Metabolite
Etilevodopa hydrochloride (L-DOPA ethyl ester) is a prodrug of levodopa. It also has greater gastric solubility and significant brain penetration.
T74180 [18F]-Labeled L-dopa precursor
[18F]-Labeled L-dopa precursor is a precursor for synthesis of 18F-labeled L-dopa[1].
T31823 Fluorodopa F 18 Fluorodopa (18F),6-(18F)Fluoro-L-DOPA,F-DOPA,L-6-(18F)Fluoro-DOPA,6-(18F)Fluorodopamine
Fluorodopa F 18 can be used as radioactive agent.
T34589 SD-1077 d3-L-DOPA,deuldopa,deuterated levodopa,SD1077
SD-1077, also known as d3-L-DOPA, is a deuterium containing levodopa. SD-1077 has been shown in preclinical models to improve the half-life of dopamine in the brain resulting in a prolonged treatment effect.
T1517 Benserazide hydrochloride Benserazide HCl,Serazide,Ro 4-4602 Dopamine Receptor
Benserazide hydrochloride (Ro 4-4602) is a peripherally-acting L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.
T7746 Eltoprazine dihydrochloride Others
Eltoprazine dihydrochloride is a drug that had previously been developed for aggression, has recently been investigated for L-DOPA-induced dyskinesia in animal models of Parkinson´s disease (PD) and in dyskinetic PD pati...
TP2050L CTAP(TFA) (103429-32-9 free base) CTAP(TFA) Opioid Receptor
CTAP(TFA) (103429-32-9 free base) is a potent, highly selective, and brain-penetrant antagonist of the μ-opioid receptor with IC50 of 3.5 nM. It displays over 1200-fold selectivity over δ opioid (IC50=4500 nM) and somato...
T8637 DMNB 6-Nitroveratraldehyde DNA-PK
DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 15 μM, an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human c...
T0115 Idazoxan hydrochloride RX 781094 Adrenergic Receptor , Imidazoline Receptor
Idazoxan hydrochloride (RX 781094) is a benzodioxane-linked imidazole. It has alpha-2 adrenoceptor antagonist activity.
T15701 Methyldopa hydrochloride L-(-)-α-Methyldopa hydrochloride,MK-351 hydrochloride Others
L-(-)-α-Methyldopa hydrochloride is an alpha-adrenergic agonist psychoactive drug. It is used as a sympatholytic or antihypertensive. Methyldopa has a dual mechanism of action. It is a competitive inhibitor of the enzyme...
T20396 Levadopa Related Compound A 6-Hydroxydopa, L-,L-Hydroxydopa
Levadopa Related Compound A is the 6-hydroxy derivative of the amino acid L-DOPA with neurotoxic properties. Exogenously administered 6-Hydroxy-L-DOPA is biotransformed by an amino acid decarboxylase to the highly potent...
T37605 D-DOPA
D-DOPA is an enantiomer of the dopamine precursor L-DOPA . It can be converted to L-DOPAviasequential oxidation and transamination, which are mediated by D-amino acid oxidase (DAAO) and DOPA transaminase, respectively, i...
T16279 Nebicapone BIA 3-202 Others
Nebicapone is a reversible catechol-O-methyltransferase (COMT) inhibitor and is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to ...
T72703 Tyrosinase-IN-11
Tyrosinase-IN-11, a potent inhibitor of tyrosinase, exhibits IC50 values of 50 nM and 64 nM for L-tyrosinase and L-dopa (L-dopa), respectively. It demonstrates significant antioxidant activity coupled with low cytotoxici...
T75917 CTAP TFA
CTAP TFA, a potent and highly selective μ opioid receptor antagonist that effectively crosses the blood-brain barrier, exhibits a significant inhibition concentration (IC50) of 3.5 nM. It demonstrates extraordinary selec...
T38145 Eltoprazine
Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.IC50 value:Target: 5-HT1A/1B agonist; 5-HT2C antagonistin vitro...
カタログ番号 製品名 別名 ターゲット
T0848 L-DOPA Levodopa,3,4-Dihydroxyphenylalanine Dopamine Receptor , Endogenous Metabolite
L-DOPA (Levodopa) is an amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier. When in the brai...
T26288 Clovamide trans-Clovamide,N-trans-Caffeoy-L-dopa Apoptosis , Influenza Virus , ROS , Antibacterial
Trans-Clovamide (trans-Clovamide) is a naturally occurring caffeoyl conjugate identified in the antioxidant polyphenolic fraction of cocoa (T. cacao L.) Trans-Clovamide is a potent antioxidantand that has shown neuroprot...
T15255 Etilevodopa Levodopa ethyl ester,L-DOPA ethyl ester Others
Etilevodopa is an ethyl-ester prodrug of Levodopa which is used for the treatment of Parkinson's disease (PD). It is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Levo...
T3737 3-(2,4-Dihydroxyphenyl)propanoic acid Hydroumbellic acid,2,4-Dihydroxyhydrocinnamic acid Tyrosinase
3-(2,4-Dihydroxyphenyl)propanoic acid (Hydroumbellic acid) is a predicted metabolite generated by BioTransformer1 that is produced by the metabolism of 3-(2, 4-dihydroxyphenyl)prop-2-enoic acid. It is generated by abkar1...
T4S1962 Beta-Asarone Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin NF-κB , JNK
1. beta-Asarone (Cis-Isoelemicin) may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in SAMP8 mice. 3. The co-administration of be...
TN1314 6-Hydroxykaempferol Tyrosinase
6-Hydroxykaempferol is a competitive inhibitor of tyrosinase compared to L-DOPA, it shows also high antioxidant activities.
TMA2419 Catalponol cAMP
Catalponol can enhance dopamine biosynthesis by inducing TH activity and protect against L-DOPA-induced cytotoxicity in PC12 cells, which was mediated by the increased levels of cyclic AMP.
T75563 Vanicoside E
Vanicoside E is an antioxidant and antitumor agent. Vanicoside E inhibits L-Tyrosine and L-DOPA with IC 50 s of 45.23 μM and 189.96 μM, respectively [1] [2] .
TN3607 Catalpalactone cAMP
Catalpalactone exhibits high antitermitic, and cytotoxic activities, it exhibits potent inhibitory effects on lipopolysaccharide-induced NO synthesis in RAW 264.7 cells , with IC50 values of 9.80 microM. Catalpalactone c...

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPY-01060 DOPA Decarboxylase/DDC Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
DOPA Decarboxylase/DDC Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 55 kDa and the accession number is Q53Y41.
TMPY-02472 DOPA Decarboxylase/DDC Protein, Mouse, Recombinant (His) Mouse Baculovirus Insect Cells
DOPA Decarboxylase/DDC Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 55.2 kDa and the accession number is O88533.