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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T31570 | DPBX-L-Dopa | DPBX L-Dopa | |
DPBX-L-Dopa is a boron-containing dopa-derivative, acting as a bladder relaxant through non-catecholamine receptors. | |||
T36122 | 3-O-methyl-L-DOPA (hydrate) | ||
3-O-methyl-L-DOPA is a metabolite of L-DOPA , produced by the activity of catechol O-methyltransferase. 3-O-methyl-L-DOPA may have effects of its own or it may compete with the actions of L-DOPA. | |||
T24047 | Etilevodopa hydrochloride | Levodopa ethyl ester,Etilevodopa HCl, L-DOPA ethyl ester | Others , Dopamine Receptor , Drug Metabolite |
Etilevodopa hydrochloride (L-DOPA ethyl ester) is a prodrug of levodopa. It also has greater gastric solubility and significant brain penetration. | |||
T74180 | [18F]-Labeled L-dopa precursor | ||
[18F]-Labeled L-dopa precursor is a precursor for synthesis of 18F-labeled L-dopa[1]. | |||
T31823 | Fluorodopa F 18 | Fluorodopa (18F),6-(18F)Fluoro-L-DOPA,F-DOPA,L-6-(18F)Fluoro-DOPA,6-(18F)Fluorodopamine | |
Fluorodopa F 18 can be used as radioactive agent. | |||
T34589 | SD-1077 | d3-L-DOPA,deuldopa,deuterated levodopa,SD1077 | |
SD-1077, also known as d3-L-DOPA, is a deuterium containing levodopa. SD-1077 has been shown in preclinical models to improve the half-life of dopamine in the brain resulting in a prolonged treatment effect. | |||
T1517 | Benserazide hydrochloride | Benserazide HCl,Serazide,Ro 4-4602 | Dopamine Receptor |
Benserazide hydrochloride (Ro 4-4602) is a peripherally-acting L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor. | |||
T7746 | Eltoprazine dihydrochloride | Others | |
Eltoprazine dihydrochloride is a drug that had previously been developed for aggression, has recently been investigated for L-DOPA-induced dyskinesia in animal models of Parkinson´s disease (PD) and in dyskinetic PD pati... | |||
TP2050L | CTAP(TFA) (103429-32-9 free base) | CTAP(TFA) | Opioid Receptor |
CTAP(TFA) (103429-32-9 free base) is a potent, highly selective, and brain-penetrant antagonist of the μ-opioid receptor with IC50 of 3.5 nM. It displays over 1200-fold selectivity over δ opioid (IC50=4500 nM) and somato... | |||
T8637 | DMNB | 6-Nitroveratraldehyde | DNA-PK |
DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 15 μM, an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human c... | |||
T0115 | Idazoxan hydrochloride | RX 781094 | Adrenergic Receptor , Imidazoline Receptor |
Idazoxan hydrochloride (RX 781094) is a benzodioxane-linked imidazole. It has alpha-2 adrenoceptor antagonist activity. | |||
T15701 | Methyldopa hydrochloride | L-(-)-α-Methyldopa hydrochloride,MK-351 hydrochloride | Others |
L-(-)-α-Methyldopa hydrochloride is an alpha-adrenergic agonist psychoactive drug. It is used as a sympatholytic or antihypertensive. Methyldopa has a dual mechanism of action. It is a competitive inhibitor of the enzyme... | |||
T20396 | Levadopa Related Compound A | 6-Hydroxydopa, L-,L-Hydroxydopa | |
Levadopa Related Compound A is the 6-hydroxy derivative of the amino acid L-DOPA with neurotoxic properties. Exogenously administered 6-Hydroxy-L-DOPA is biotransformed by an amino acid decarboxylase to the highly potent... | |||
T37605 | D-DOPA | ||
D-DOPA is an enantiomer of the dopamine precursor L-DOPA . It can be converted to L-DOPAviasequential oxidation and transamination, which are mediated by D-amino acid oxidase (DAAO) and DOPA transaminase, respectively, i... | |||
T16279 | Nebicapone | BIA 3-202 | Others |
Nebicapone is a reversible catechol-O-methyltransferase (COMT) inhibitor and is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to ... | |||
T72703 | Tyrosinase-IN-11 | ||
Tyrosinase-IN-11, a potent inhibitor of tyrosinase, exhibits IC50 values of 50 nM and 64 nM for L-tyrosinase and L-dopa (L-dopa), respectively. It demonstrates significant antioxidant activity coupled with low cytotoxici... | |||
T75917 | CTAP TFA | ||
CTAP TFA, a potent and highly selective μ opioid receptor antagonist that effectively crosses the blood-brain barrier, exhibits a significant inhibition concentration (IC50) of 3.5 nM. It demonstrates extraordinary selec... | |||
T38145 | Eltoprazine | ||
Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.IC50 value:Target: 5-HT1A/1B agonist; 5-HT2C antagonistin vitro... |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T0848 | L-DOPA | Levodopa,3,4-Dihydroxyphenylalanine | Dopamine Receptor , Endogenous Metabolite |
L-DOPA (Levodopa) is an amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier. When in the brai... | |||
T26288 | Clovamide | trans-Clovamide,N-trans-Caffeoy-L-dopa | Apoptosis , Influenza Virus , ROS , Antibacterial |
Trans-Clovamide (trans-Clovamide) is a naturally occurring caffeoyl conjugate identified in the antioxidant polyphenolic fraction of cocoa (T. cacao L.) Trans-Clovamide is a potent antioxidantand that has shown neuroprot... | |||
T15255 | Etilevodopa | Levodopa ethyl ester,L-DOPA ethyl ester | Others |
Etilevodopa is an ethyl-ester prodrug of Levodopa which is used for the treatment of Parkinson's disease (PD). It is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Levo... | |||
T3737 | 3-(2,4-Dihydroxyphenyl)propanoic acid | Hydroumbellic acid,2,4-Dihydroxyhydrocinnamic acid | Tyrosinase |
3-(2,4-Dihydroxyphenyl)propanoic acid (Hydroumbellic acid) is a predicted metabolite generated by BioTransformer1 that is produced by the metabolism of 3-(2, 4-dihydroxyphenyl)prop-2-enoic acid. It is generated by abkar1... | |||
T4S1962 | Beta-Asarone | Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin | NF-κB , JNK |
1. beta-Asarone (Cis-Isoelemicin) may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in SAMP8 mice. 3. The co-administration of be... | |||
TN1314 | 6-Hydroxykaempferol | Tyrosinase | |
6-Hydroxykaempferol is a competitive inhibitor of tyrosinase compared to L-DOPA, it shows also high antioxidant activities. | |||
TMA2419 | Catalponol | cAMP | |
Catalponol can enhance dopamine biosynthesis by inducing TH activity and protect against L-DOPA-induced cytotoxicity in PC12 cells, which was mediated by the increased levels of cyclic AMP. | |||
T75563 | Vanicoside E | ||
Vanicoside E is an antioxidant and antitumor agent. Vanicoside E inhibits L-Tyrosine and L-DOPA with IC 50 s of 45.23 μM and 189.96 μM, respectively [1] [2] . | |||
TN3607 | Catalpalactone | cAMP | |
Catalpalactone exhibits high antitermitic, and cytotoxic activities, it exhibits potent inhibitory effects on lipopolysaccharide-induced NO synthesis in RAW 264.7 cells , with IC50 values of 9.80 microM. Catalpalactone c... |
カタログ番号 | 製品名 | Species | Expression System |
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TMPY-01060 | DOPA Decarboxylase/DDC Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
DOPA Decarboxylase/DDC Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 55 kDa and the accession number is Q53Y41. | |||
TMPY-02472 | DOPA Decarboxylase/DDC Protein, Mouse, Recombinant (His) | Mouse | Baculovirus Insect Cells |
DOPA Decarboxylase/DDC Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 55.2 kDa and the accession number is O88533. |